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Cryo-EM Supplies

AutoGrid & Clipping Tools

AutoGrid Tweezers
NEW Clipping Station
AutoGrid Tweezers
NEW Clipping Tools
AutoGrid Tweezers
NEW C-Clip
Bottoming Tool
autogrid and clipping tools
NEW AutoGrid
autogrid and clipping tools
NEW AutoGrid
Inspection Tool
thermo fisher fei vitrobot supplies
Thermo Fisher/FEI
Vitrobot Supplies
Vitrobot - Cryo Grid Boxes
Cryo Grid Boxes

Cryo Grid Box
Handling Tools

NEW Clipping Station

NanoSoft’s Clipping Station provides unmatched ease of use and efficiency for the clipping of Cryo-EM grids (known as autogrids) for Thermo Fisher autoloader-based microscopes.

AutoGrid Tweezers AutoGrid Tweezers AutoGrid Tweezers
Clipping Station
Clipping Hub
AutoGrid Placement

A high quality foam dewar integrates grid box and clipping tool access directly adjacent to the clipping space, increasing ease of use and reducing the potential for contamination. Furthermore, the Clipping Station comes with a puck sized holder for clipping tools, such that up to 33 tools can be pre-loaded with c-clips and placed in the holder to be cooled down while in a position that is easy to access, enabling seamless clipping of up to 33 samples at one time. A new Clipping Hub design makes the workflow easier, and a well-designed lid balances ease of use and protection. The opening in the lid provides the ideal amount of space to access the entire clipping hub without needing to rotate the lid, and while providing protection from ambient humidity. Knobs on the lid enable easy turning to access and transfer other grid boxes or clipping tools to the Hub, and a Lid insert can cover the entire opening so that the clipping space can be closed off from the ambient environment completely during cool down and as needed. Furthermore, our Clipping Station is compatible with both NanoSoft (#47000-611) and Thermo Fisher clipping tools.

Clipping Station Features:

  • Foam Dewar - High quality, durable, closed-cell polyethylene
  • Clipping Hub – newly designed for ease of use
  • Clipping Tool Puck - holds up to 33 clipping tools
  • Lid - provides optimal balance between usability and separation of the clipping space from the ambient environment
  • Silicone Mat - reduces station movement when rotating the lid
  • Compatible with Cryo Grid Box Storage Pucks - grid boxes can be accessed without needing to transfer them through the ambient environment from another dewar

Other clipping stations typically utilize a rotating brass guidance cylinder, which is often difficult to turn and can bend tweezers. The clipping hub of this station utilizes a novel ‘seesaw’ mechanism for moving the guidance cylinder into and out of position. This mechanism requires the user to push down on either side of the cantilever beam to move the guidance cylinder into the position for clipping or for placement/removal of the autogrid ring. The shallow hole where the autogrid ring is placed for clipping has a dark colored surface to provide better contrast and tracking when placing an autogrid ring and picking up a clipped grid with autogrid tweezers.

Clipping Hub Features:

  • Easy to use ‘Seesaw’ mechanism
  • 4 built-in grid box pockets
  • 4 "on-deck" positions for clipping tools
  • High contrast AutoGrid ring cavity
  • Grooves for inspection of clipped grids and cryo-ET/FIBSEM ring notch orientation

Prod # Description Unit Price Order / Quote
47000-615 Clipping Station each $2572.00
47000-616 Clipping Station with 8-Pack Kit of Clipping Tools each P.O.R.
47000-617 Clipping Station with 16-Pack Kit of Clipping Tools each P.O.R.

AutoGrid Tweezers
Clipping Tool

NEW Clipping Tools

NanoSoft’s Clipping Tool is loaded with C-clips and clips grids the same way as the Thermo Fisher version, and is compatible with the Thermo Fisher clipping station. The difference is that instead of ejecting the C-clip by pressing a long plastic handle, you press on our tool with a pair of tweezers. This version has the advantage of a compact design so that when they are placed in LN2 in the clipping station to be cooled down, the entire body is deep enough inside the station that they are untouched by any frost from environmental moisture, even when left in the station at cryogenic temperature for long periods of time. This means you can pre-load as many of our tools with C-clips as you would like, cool them all down at the same time, and then clip all your grids at one time without with little consideration for ice contamination - no need to warm, re-load and re-cool clipping tools.

After loading the Clipping Tools with C-clips, place them into the Clipping Tool Rack, and then place the rack with Clipping Tools into a clipping station for cooling. These tools can be placed directly into the NanoSoft Clipping Station (#47000-615) without the need for the supplemental rack. When ready to clip, use any type of tweezer to grab the back end of the Clipping Tool - the square profile of the plunger/back end enables simple and comfortable grasping with tweezer tips. Small protuberances provide extra support to keep the Clipping Tool from twisting when transferring from the rack to the grid. We recommend using Autogrid Tweezers - the Clipping Tools remains very securely in position during the transfer. Place the Clipping Tool into position for clipping and release the tool; we recommend pressing down on the top of the Clipping Tool to eject the C-clip and clip the grid, i.e. not while grasping the sides of the plunger with the tweezers. This will help you ensure that you can keep the tweezers straight while pressing the plunger - you will find that the shorter body of our Clipping Tool enables you to keep the tool straighter than competitor clipping tools while clipping, which helps ensure that C-clip properly seats into the autogrid ring.

The C-clip Bottoming Tool provides an easier and more efficient way to "bottom" the C-clip at the tip of the barrel of a clipping tool prior to clipping. After pressing the C-clip into the barrel of the tool, instead of pressing the tip of the barrel against the tabletop or a pair of tweezers to push the c-clip to the tip of the barrel (by pressing the plunger), you place the barrel into the Bottoming Tool and press the plunger of the tool to bottom the C-clip. The cylinder of our Bottoming Tool ensures that the barrel of the clipping tool is straight, so upon pressing of the plunger to push the C-clip to the tip you are much less likely to "mis-bottom" the C-clip. Often when pressing the tip against the table top or another flat surface, you are not able to hold the barrel exactly straight against the surface and you the c-clip can fly out of the tool and is lost. Our Bottoming Tool provides an easy way to ensure you don't mis-bottom C-clips anymore.

47000-612 Kit Contents:
4 Clipping Tools
1 Clipping Tool Rack
1 C-clip Bottoming Tool

AutoGrid Tweezers
Clipping Tool Rack
shown with Clipping Tools
AutoGrid Tweezers AutoGrid Tweezers
C-clip Bottoming Tool

Prod # Description Unit Price Order / Quote
47000-611 Clipping Tool each $268.00
47000-613 Clipping Tool Rack each 27.00
47000-614 C-clip Bottoming Tool each 43.00
47000-612 Clipping Tools, 4-Pack Kit each 965.00

AutoGrid Tweezers

NEW AutoGrid Tweezers

The AutoGrid Tweezers are designed to handle the Thermo Fisher/FEI AutoGrids. The tweezer tip has a step cut out that enables the user to securely hold the AutoGrid while transferring it from the clipping station to the cassette. 
AutoGrid Tweezers

Prod # Description Unit Price Order / Quote
47000-600 AutoGrid Tweezers each $395.00

cryo grid box handling rod

NEW AutoGrid Inspection Tool

NanoSoft's AutoGrid Inspection Tool is a low-cost way of performing a last autogrid inspection step prior to loading them into the cassette. It is placed into a grid box spot in the Thermo Fisher/FEI cassette loading station and will remain there securely due to the spring-loaded detent on the side of the tool. 

AutoGrids can be placed in the groove of the AutoGrid inspection tool and quickly flipped back and forth to check that the grid is securely clipped. It provides a final, low-cost check to help ensure only well-clipped grids are loaded into the autoloader, saving the potential disaster of a poorly clipped grid coming undone in the autoloader and weeks of downtime.

Prod # Description Unit Price Order / Quote
47000-610 AutoGrid Inspection Tool each $92.00