Material Safety Data Sheet
Product No. 18459, 18463, 18465 Osmium Tetroxide, 4% Aqueous
Issue Date (02-11-05)
Review Date (09-15-06)
Section 1: Product and Company Identification
Product Name: Osmium Tetroxide, 4% Aqueous
Synonym: Osmium Tetroxide, Osmic Acid Solution, Osmium (VIII) Oxide
Chemical Family: Platinum Group
Metal Salts
Company Name
Ted Pella, Inc. and PELCO International, P.O. Box 492477, Redding, CA
96049-2477
Domestic Phone (800) 237-3526 (Mon-Thu. 6:00AM
to 4:30PM PST; Fri 6:00AM to 4:00PM PST)
International Phone (01) (530) 243-2200 (Mon-Thu. 6:00AM to 4:30PM PST;
Fri 6:00AM to 4:00PM PST)
Chemtrec Emergency Number 1-800-424-9300 24 hrs a day.
Section 2: Composition / Information on Ingredients
|
Principle Hazardous Component(s)
|
% |
OSHA mg/m3 |
ACGIH |
NTP |
IARC |
OSHA |
|
Osmium Tetroxide/Osmium Oxide (20816-12-0) |
4 |
0.002 |
0.002 |
No |
No |
No |
Section 3: Hazard Identification
Emergency overview
Appearance: Colorless to pale
yellow solution.
Immediate effects: This
substance can be absorbed into the body by inhalation of its vapors, by
inhalation of its aerosol and by ingestion. May cause sensitization
by inhalation and skin contact.
Target Organs: Eyes and Central
Nervous System.
Potential health effects
Primary Routes of entry: Eyes:
Likely; Inhalation: Highly; Skin: Likely; Ingestion: Likely
Signs and Symptoms of Overexposure:
Eyes: Irritation, lacrimation, visual disturbance, conjunctivitis, headache,
potential damage to cornea.
Skin: Dermatitis, possible skin
discoloration (green or black).
Ingestion: Irritation, cough, dyspnea, death.
Inhalation: Coughing, shortness
of breath, unconsciousness, could cause tracheitis,
bronchitis, bronchial spasm which may lead to inflammatory lesions of the lung.
Chronic Exposure: Potential Kidney damage.
Chemical Listed As Carcinogen Or Potential
Carcinogen: No
See Toxicological Information (Section11)
Potential environmental effects
See Ecological Information (Section 12)
Section 4: First Aid Measures
If accidental overexposure is suspected
Eye(s)
Contact: Flush for 15 minutes with plenty of water. If discomfort occurs
or persists, contact a physician.
Skin Contact: Flush area for 15
minutes with water and wash with soap and water. If discomfort occurs or
persists, contact a physician. Remove contaminated clothing and shoes and wash
before reuse.
Inhalation: If swallowed give large quantities of water and induce vomiting
unless person is unconscious. Get medical attention immediately.
Ingestion: Remove to fresh air
immediately. If discomfort occurs or persists, contact a physician. If
breathing has stopped, perform artificial respiration.
Note to physician
Treatment: ND
Medical Conditions generally
Aggravated by Exposure: Any respiratory condition such as asthma will be
aggravated. Potential kidney damage.
Section 5: Fire Fighting Measures
Flash Point: NA
Flammable Limits: NA
Auto-ignition point: NA
Fire Extinguishing Media: Water spray, carbon dioxide, and dry chemical.
Special Fire Fighting Procedures: Use NIOSH/MSHA
approved self-contained breathing apparatus and full protective clothing.
Unusual Fire and Explosion Hazards: Osmium tetroxide is a strong oxidizer and
may react explosively with many organic compounds.
Hazardous combustion products:
DOT Class: Toxic, 6.1
Section 6: Accidental Release
Measures
Steps to be Taken in Case Material is Released or Spilled: Clean up immediately
using recommended personal protection. Remove material to a fume hood or other
well ventilated area. Person protected with self-contained breathing apparatus
with full face piece.
Waste Disposal Methods: Dispose of waste according to Federal, State and Local
Regulations.
Section 7: Handling and
Storage
Precautions to be Taken in Handling and Storage: If eyes are exposed to vapor
over a short period of time, night vision will be affected for about one
evening. One will notice colored halos around lights. Store sealed vials in a
dry, cool area (refrigerator) with sufficient packaging to avoid accidental
breakage. Use compatible chemical-resistant gloves. Wash hand thoroughly after
handling. Avoid breathing dust or solution spray. Avoid contact with eyes.
Avoid contact with skin and clothing. Have emergency SCBA
or SAR. Use only with adequate ventilation. Wash hands before eating, drinking,
or smoking. Do not store directly on ground. Do not store near combustible
materials. Keep container upright. Store in a dry place.
Other Precautions: 0.1 mg.m3 supplied air respirator with a full face
piece, any self-contained breathing apparatus with a full face piece. Any chemical cartridge respirator with a high efficiency
particulate filter with a full face piece and cartridges providing protection
against osmic acid. Any
air-purifying full face piece respirator (gas mask) with a chin style or front
or back mounted canister providing protection against osmium tetroxide and
having a high efficiency particulate filter. 1 mg/m3 any supplied air
respirator with a full face piece and operated in a pressure-demand or other
positive pressure mode. Emergency or planned entry in unknown
concentration or immediately dangerous to life or heath conditions. Any
self-contained breathing apparatus with full face piece and operated in a
pressure-demand or other positive pressure mode. Any
self-contained breathing apparatus. Escape: Any air-purifying full face
piece respirator (gas mask) with a chin-style or front or back mounted canister
providing protection against osmium tetroxide and having a high efficiency
particulate filter. Any appropriate escape type self-contained breathing
apparatus.
Storage temperature: ND
Storage Pressure: ND
Section 8: Exposure Controls / Personal Protection
Engineering Controls
Ventilation required: Local
Exhaust: Yes; Mechanical: Yes; Other: Fume Hood.
Personal Protection Equipment
Respiratory protection: 0.1
mg/m3 supplied air respirator with a full face piece.
Protective gloves: Rubber/Neoprene
(use compatible chemical-resistant gloves).
Skin protection: Lab coat/apron, flame and chemical resistant protective
clothing.
Eye protection: ANSI approved safety glasses/goggles or full face piece with
respirator.
Additional clothing and/or equipment: eye wash, safety shower, and hygiene
facilities for washing.
Exposure Guidelines
See Composition/Information on Ingredients (Section2)
Section 9 Physical and Chemical Properties
Appearance and Physical State: Colorless to pale yellow solution.
Odor (threshold): Sharp chlorine
like odor.
Chemical Type: Mixture
Specific Gravity (H2O=1): NE
Vapor Pressure (mm Hg): NA
Vapor Density (air=1): NA
Percent Volatile by volume: ND
Evaporation Rate (butyl acetate=1): NE
Boiling Point: 100 ?C
Freezing point / melting point: NA
pH: 6 ? 7
Solubility in Water: 5g OsO4/100 ml
Molecular Weight: 254.2
Chemical Formula: OsO4 in H2O.
Section 10: Stability and Reactivity
Stability: Stable
Conditions to Avoid: Elevated temperature. Contact with Hydrochloric acid will
cause formation of poisonous chlorine gas.
Materials to Avoid (Incompatibility): Organic materials, hydrochloric acid,
bases, and chlorine gas.
Hazardous Decomposition Products: None
Hazardous Polymerization: Will not occur.
Section 11: Toxicological Information
Results of component toxicity test performed: LC50 (Mouse, Rats): 40 ppm (400 mg/m3). LD50 (Inhalation, Rabbits): 1316
mg/m3). Exposure Time: 30 mins. Results:
Caused pulmonary edema and death after 4 days. LD50 (Oral, Mouse): 162 mg/kg.
LD50 (Intraperitoneal, Mouse): 13.5 mg/kg bw.
LD50 (Intraperitoneal, Rat): 1401 mg/kg bw.
(ACG98)
Human experience: In low (not specified) levels of Osmium tetroxide (OsO4)
caused irritation in the eyes, skin, nose and respiratory system. In high
(not specified) levels, it may be corrosive to the eyes and the skin and also
may cause systemic effects, pneumonia and lethality. Tolerated
concentration: 0.001 mg/m3 for 6 hours. Repeated
or prolonged contact with skin man cause dermatitis.
The substance may cause effect on the kidney.
This product does not contain any compounds listed by NTP or IARC or
regulated by OSHA as a carcinogen.
Section 12: Ecological Information
Ecological Information: This substance may be hazardous to the environment;
special attention should be given to Crustacea.
Chemical Fate Information: NIF
Section 13 Disposal Considerations
RCRA 40 CFR 261 Classification:
OsO4 is a listed EPA Hazardous Waste - P087. Crystals and solutions may
be dissolved and/or neutralized in an aqueous solution of sodium or potassium
hydroxide (approx. 25%). Consult Federal EPA, State and local regulations for
proper disposal/recycle/reclamation material may make the waste management
information presented above incomplete, inaccurate, or otherwise inappropriate.
Federal, State and local laws governing disposal of materials can differ.
Ensure proper disposal compliance with proper authorities before disposal.
Section 14: Transportation Information
Note: Osmium Tetroxide is NOT classified as a vapor inhalation hazard
by US DOT or IATA.
US DOT Information:
Proper shipping name: Toxic liquid, inorganic, n.o.s. (Osmium tetroxide in 4%
aqueous solution).
Hazard Class: 6.1
Packaging group: PG-III
UN Number: UN3287
IATA: Proper shipping name: Toxic liquid, inorganic, n.o.s. (Osmium
tetroxide in 4% aqueous solution).
Hazard Class: 6.1
Packing group: PG-III
UN Number: UN3287
Domestic shipments only:
IMO: Proper shipping name: Toxic liquid, inorganic, n.o.s. (Osmium tetroxide
in 4% aqueous solution).
Class: 6.1
UN Number: UN3287
Packing group: PG-III
ERG Code (Emergency Response Guidance for Aircraft Incidents): 6L????? Explanation of Code: Drill number: 6
Toxic, Drill letter: L Other risk low or none.
MFAG: ND
Marine Pollutant: Severe marine pollutant. RQ: 1000 lbs (454 kg).
Canadian TDG: ND
IMDG Page: PP
Section 15: Regulatory Information
United States Federal Regulations
MSDS complies with OSHA?s Hazard Communication Rule 29, CFR 1910.1200.
SARA: Osmium tetroxide. CAS# 20816-12-0. De MINIMIS
conc.: 1.0. %Rep. Threshold.: not listed.
SARA Title III: Section 313: Acute: Yes. Chronic: Yes. Flammability: No.
Pressure: No Reactivity
RCRA: Osmium Tetroxide/Osmium
Oxide: RCRA Hazardous Waste: P-Series
TSCA: This chemical is TSCA
listed, and is also classified with FDA as an IVD.
CERCLA: Osmium Tetroxide/Osmium Oxide (20816-12-0): RQ = 1000 lbs (454 kg).
State Regulations
California Proposition 65: No
International Regulations
Canada WHMIS: This product has been classified in accordance with the hazard
criteria of CPR, and the MSDS contains all the information required by the CPR.
Europe EINECS Numbers: Osmium Tetroxide/Osmium
Oxide (20816-12-0): EINECS#: 244-058-7.
Section 16: Other Information
Label Information: Toxic
European Risk and Safety Phrases: Risk #: 39/23/24/25. Risk Phrases: Toxic;
Danger of very serious irreversible effects through inhalation, in contact with
skin and if swallowed. Safety #: 1/2 -7/9-26-45. Safety Phrases: Keep locked up
and out of reach of children, keep containers tightly closed and in a well
ventilated place. In case of contact with eyes, rinse immediately with plenty
of water and seek medical attention. In case of an accident or if you feel
unwell, seek medical advice immediately. (Show label when possible).
European symbols needed: T+
Canadian WHMIS Symbols: ND
HMIS Hazard Rating: Health: 4; Fire: 0;
Reactivity: 1 Personal Protection: J
NFPA Hazard Rating: Health: 4; Fire: 0;
Reactivity: 1 Other: TOX
(0=least, 1=Slight, 2=Moderate, 3=High, 4=Extreme)
Abbreviations used in this document
NE= Not established
NA= Not applicable
NIF= No Information Found
ND= No Data
Disclaimer
Ted Pella, Inc. makes no warranty of any kind regarding the information furnished
herein. Users should independently determine the suitability and completeness
of information from all sources. While this data is presented in good faith and
believed to be accurate, it should be considered only as a supplement to other
information gathered by the user. It is the User's responsibility to assure the
proper use and disposal of these materials as well as the safety and health of
all personnel who may work with or otherwise come in contact with these
materials.
MSDS Form 0013F1 V2